Development of Bioactive glass based scaffolds coated with metal-loaded hydroxyapatite nanocomposites as potential biomaterials for bone tissue repair


Investigator: María Laura Dittler (Visiting PhD student, National University of La Plata, Argetina)

María Laura Dittler


Supervisor (La Plata): Prof. Dra. Mónica Cristina Gonzalez (Director)

Supervisor (FAU): Prof. Dr. Ing. Aldo R. Boccaccini


Ion substitution has been proposed as a strategy for improving the physicochemical and biological response of synthetic HAp [1]. On the other hand, a very relevant group of biomaterials for bone regeneration are bioactive glasses, which can be made into 3D scaffolds of suitable porosity for bone regeneration [2] and have been shown to support osteoblast cell attachment and to have angiogenic effects [3, 4]. The design of bioactive glasses with specific ion release ability has acquired significant attention recently [4]. However, the construction of bioactive glass scaffolds incorporating metal-doped hydroxyapatite nanostructures (n-HAp) has not been investigated. The goal of this project is to use current technology to design and fabricate scaffolds coated with metal-doped n-HAp. Nanocomposites doped with metal ions were synthesized and further characterized at the Institute for Theoretical Applied Physicochemical Research (INIFTA) under the direction of Prof. Dra. Mónica Cristina Gonzalez. At the Institute of Biomaterials in Erlangen, scaffolds based on silicate bioactive glass 45S5 are obtained by the foam replica technique [2]; through the immersion method the coating with HA nanocomposites are produced. Furthermore, chemical-physical characterization and mineralization assays are carried out. The biological compatibility of the obtained materials will be tested by cell viability and proliferation tests.

[1] Bose, S. et al., Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics. Trends in Biotechnology 2013; 31: 594-605.

[2] Chen QZ, Thompson ID, Boccaccini AR. 45S5 Bioglass®-derived glass-ceramic scaffolds for bone tissue engineering, Biomaterials 2006;27:2414–25.

[3] Gorustovich AA, Roether JA, Boccaccini AR. Effect of bioactive glasses on angiogenesis: a review of in vitro and in vivo evidences. Tissue Eng Part B Rev. 2010; 16:199-207.

[4] Hoppe, A., et al., A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics, Biomaterials 2011; 32: 2757-2774.